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Thursday, April 16, 2026

Injectables & Adherence...

 

Since the beginning of HIV treatment, the game has been the same.  Medications have to be accessible, tolerable & reliable.  Then there's adherence.  The best meds in the world won't matter if they aren't taken regularly. 

90 - 95% adherence is what's needed for HIV meds to be effective & help prevent resistance.  The aim was to create regimens that were accessible with ease of regimen maintenance.  We went from handfuls of pills to a few, to a single pill.  Now there are injectable options given weekly, monthly, quarterly & at larger intervals.  Until a cure is found, they'll probably aim for annual injections.

For many adherence is a serious challenge.  Injectables could be a much better option for many.  After taking handfuls of pills daily, a single dose at wide intervals would be astounding.  Even if it was a weekly pill, that would be a drastic improvement.  

Adherence makes this all work.  Any threat to that is a threat to that person.

Cya...

Wednesday, April 15, 2026

Mid-April...

 

I'm trying to get more sleep, but these hazy mornings aren't helping.  I'm still tired.  Things could get chilly weekend.  I was hoping to be to a point where it was warmer, brighter & we had more of the BS on our plate handled.  That's not happening.

Yesterday's outing didn't go as well as hoped for.  There's more left up in the air.  The bees are still here & I'm beginning to think the guy we called flaked out.  

I wish I could post something about HIV or less negative.   There weren't any good articles & I haven't had anything good to post about in a long time.    This is it for today.

Take care.

Cya...

Tuesday, April 14, 2026

Another Tuesday Outing...

 

We have another outing.  At least it wasn't super early this time.  We'll head out soon.

I slept better, but not so much on the waking part.  It's cloudy & may rain tonight.   Mornings like this aren't good for me.  Then again nothing much regarding my sleep has been all that great for some time.  

We have things to handle & I'll get through them, but I'm already tired.  I wish I had something that would make all of this easier on me, but I don't.  I'm doing what I can & it's seems to be less & less.

I need to get around, take care.

Cya...

Monday, April 13, 2026

Such A Monday...

 


I didn't sleep well last night.  Everything kept making noise.  The stupid cat kept charging the window to shoo an outdoor cat.  I had to push her out of my room & close the door.  She tried to get  in & rattled the door for a while.  It made my room stuffy.

I tried to call for a refill with my pharmacy, but my medical provider hadn't provided new refills.  Now I'm waiting for that.  It'd be nice if people could just do their jobs.  

There's a lot going on & there will stuff up in the air for a while.  I'll be lucky if crap settles down before Summer starts.  A lot of people just need to die for making everyone else's life so much more difficult.

That's all for this morning.  I still have shower, go shopping & yes I'm running late.

Cya...

Sunday, April 12, 2026

More More More...

 

We had a bit of good news Friday & I should've known that wasn't actually a good thing.   A single thing off our load & we got more dumped on us almost immediately.  Besides the ongoing issues with this damn house.  There's another health issue & the asshat bees have returned.  I can't do anything about either issue.  

We're still finding out things & who knows how long this take.   Of course the weather is supposed to crap out.  Add to all of this, a male cat has decided he's a singer & won't shut up.   He's been going all morning.

Yesterday was hard.  I'm not sleeping well.  I spent most of the day with a low, anxious buzz.  I'm so over it even my cheeks feel tired.  I'm want everything to shut up & work.  If this is all that's left in my life, just let me off the ride.

Cya...

Saturday, April 11, 2026

Neighborhood Noise...

 

For a long time this neighborhood was pretty empty & little too quiet.  It bordered on creepy.  Then people moved in & there was more presence.  That in itself was not a bad thing.  Sure some of our neighbors are mow junkies, but that's not usually a problem.

For a while now, the traffic in our area has increased.  These aren't locals, they're passing through.  They're very noisy.  The trains running in our area have increased, gotten faster, longer & far louder.   I used to just sleep through trains, but now a lot of them wake me.  I'm not sure why, but we have an abundance of sirens at night.  They don't come nearby, they're just cutting through.  

This morning some asshat decided to mow at dawn with a giant mower.  It was loud & stupid.  I understand mowing early when it's hot, but we're may hit 80° today.  It also dumped nearly 0.5" yesterday afternoon.  The grass is still soaked.

I'm glad we have neighbors & the area isn't a ghost town any more, but the noise is ridiculous.  Still most of it isn't the people living nearby, it's jerks passing through, trains, sirens & landlords with huge lawn mowers.

There's my rant for this morning.  Take care.

Cya...

Friday, April 10, 2026

Back To Morning Ugh...

 

Even with the light, mornings have been really hard lately.   I wake up & I'm fine for a little bit & then it hits me.  It's not panic.  It's just a sense of everything being off & so much that I'm practically vibrating.  

My cat can vibrate when she's angry, but this is something else.  I'm not raging or panicking.  It's like I'm trying to expel or shed something.  Everything in the morning seems so much more urgent, demanding & loud. 

Whatever it is, it's overwhelming & tiring.  It takes me a while to shake it.  It's usually passed by the time my morning routine is done.  During that time, I'm an irritable mess.  Maybe this is my body finally dealing with all the SAD issues & trying to rid itself of it.  Whatever it is, I hope it fades soon.

Cya...