Different & Same Old....

 

I was going to post about this article yesterday, but things happened.  It's from AmFAR & it's recognizes the current limits of HIV regimens, mostly ARTs.  It proposes the use of immunotherapy to extend the benefits of current meds.  It focused on broadly neutralizing antibodies (bNAbs) and an immune-stimulating agent (a TLR9 agonist).  This wasn't proposing a cure, but a step in a new direction for treating HIV.  Maybe, if this works, it could lead to a functional cure.

I haven't been doing well.  I'm just tired, detached &  ready just to let go.  This has been exhausting.  2026 is going to bring a lot changes to my assistance programs.  The orange asshats say it's for health.  They don't care about any poor person's well being.  They just get off on punching down & harming those who can't really fight back.  If every orange follower would just die, the world would be a better place.

My sister called.  The call itself was benign.  I guess she needed to touch base with me, so she could say did.  Between everything going one, the time of the year, the alleged holiday happening & governmental BS, I'm just over it.   That call just reminded me or how much of an afterthought I've always been to those people related to me.  If I wasn't that I was a bother or nuisance to them.  I have a hard time seeing my life being any worse if I'd never met any of my relatives. 

I didn't need to see 59, another holiday season or 2026.  There won't be anything for me.  My life will continue to descend into worse levels.  So yeah, I don't care about 2026.  It'll only be a worse version of 2025.

Sorry for the bummer, but do give the article a read.  It could be a new direction for HIV treatment.  Take care.

Cya...

Interrupted..

 

I was going to post on something else, but I got a phone call & things went sideways.  I'll try to post more tomorrow.   Sorry about the short post.

Cya...

Next To Last Friday...

 

There's only 1 more Friday left in 2025.  There's less than a week until Christmas & not even 2 weeks left in the year.   I've said it a lot the last few years, none of this feels like the holidays.  The sparkle, wonder & anticipation of the season is just gone.  I doubt I'll live to see it again.  It might pop in small bits or places that put on a show like Silver Dollar City, but I think the twinkle has left the building.  

My roomie has a lot on her plate today.  So, shopping will need to be handled a bit quicker than usual.  She'll handle her family event this weekend & we'll do whatever we're going to next week.  We'll see what that turns out to be.

That's it for now.   Take care.

Cya.

Beware The Corti's...

 

Cortisol is a necessary hormone that affects a variety of bodily functions; waking, breathing, metabolism...  Normally it works, but some of us have issues with the cortisol awakening response (CAR).  For most people waking is just a part of the day.  

For people with a non typical CAR, it can mean difficulty waking or jolting.  I typically have the jolt.  It can leave me anxious, jittery, angry or panicked.  It doesn't usually last long, under an hour, but it ruins my morning & exhausts me.  I can stay edgy until I get a decent night's sleep again without a bad waking.

These surges can make you feel like you're under a lot of stress.  There are jitters, your heart races, concentration is shot, rapid breathing & blood pressure can rise, etc...  Cortisol can impact a lot of the body.  It can make you emotional, panicky & manic.

This article is about calming cortisol issues.  Maybe some of them will work for you.  I haven't had the best of luck, but I'm also dealing with SAD. 

This piece started me down this rabbit hole.  It's about an HIV+ woman who was prescribed a corticosteroid as part of her treatment.  Steroids are common for treating breathing issues & pneumonia.   That's where all the normal went out the window.

Shortly after, the patient was began having symptoms of manic episodes.  Corticosteroids are a manufactured version of Cortisol.  It has many of the hormone's benefits, but also the less desirable qualities.  A person with no psychiatric history had to be further hospitalized for manic episodes due to these medications.

This graph is from the article.  It shows the course of this experience from onset of the med, to removal from, to discharge.   This woman lost nearly 2 weeks of her life to a psychiatric condition due to a reaction to standard medication.

Cortisol & its derivatives are powerful hormones/chemicals.  They can alter your world in ways you wouldn't suspect.  Mine is made worse due to SAD & thyroid issues.  This is an article you should read if you have cortisol issues, use similar meds, have waking issues or are dealing unusually rough mornings.

Take care.

Cya...

Jargonized...

 

I'm not sure if this was intentional or not.  But there were a lot of articles out this morning hiding behind heavy handed writing & jargon to disguise they were topics already covered ad nauseum.  The pieces not on repeat & shuffle, were presented as imminent when they were mostly in the research stage or even earlier.  

Delivering half-baked, wordy, jargon heavy pieces doesn't help anyone or thing.  It comes off somewhere between desperate & arrogant.   Some sites seem to be trying to maintain a certain flow.  It's not easy at this time.  Funds are short & some sources are no longer as credible as they once were.  Think sites the US gov has anything to do with or if RFK has touched it. 

Were at a time when information regarding just about anything needs to be scrutinized.  Too many people are putting their "special" touches on everything.  To hell with the orange stain & his herd of ugly pig people.

That's all for now.  Take care.  Just 7 days to Christmas Eve.

Cya.

HIV In 2025...

 

The articles are starting to review the year.  There have been some high points like Gilead's lenacapaivir or Yeztugo the twice a year injection for prevention.  There  are new daily meds being developed.  Researchers have made some headway in other means to fight HIV & it's reservoirs, such as cancer treatments.   

Still, there's been the dark cloud of abrupt fund cutting.  This is all due to that orange bastard.  IMO, everyone single new case or death from HIV & similar ailments is in some part his fault.  He probably gets off on knowing that.  Between his cuts & ongoing combat throughout some regions, the fight against HIV/AIDS could be drastically set back.

There's not happening today, so this is it.  Take care.

Cya...

Same Chilly Same...

 

It's still cold & article land is lacking.  It's supposed to be warmer tomorrow & stay fairly warm for the week.  Most articles were still dealing with funding cuts & rising transmission rates in some areas.  There were some on Gilead's new 2-drug combo.  It's a single dose pill with lenacapavir that's in the 3rd stage of research.  If it gets approval, this would add to available regimens for people living with HIV.  It would further the use of lenacapavir, which should lower the price.  Soon, most people will have single dose or long acting options.  That's a far cry from where these regimens started.

That's about it for now, take care.

Cya...