From the start, this piece is a bit complex for jargon novices. It's over the interaction of HIV & interferons. The body uses interferons to fight viruses, such as HIV or COVID. They are cytokines just like in COVID-19. Even as part of our immune system they can go to extremes.
In a normal reaction, they can cause inflammation that can lead to flu-like symptoms; fever & muscle aches. In extreme cases they can lead to serious health issues as seen in COVID reactions.
This article goes over interferons interaction with HIV. It discusses their presence in people who maintain higher viral loads. HIV & some meds can lead to higher levels of interferon activity. Give the article a read.
Cya...
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